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Fibrin and poly(lactic-co-glycolic acid) hybrid scaffold promotes early chondrogenesis of articular chondrocytes: an |
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| Authors: | Munirah Sha'ban Soon Hee Kim Ruszymah BH Idrus Gilson Khang |
| Affiliation: | (1) Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia;(2) Tissue Engineering Laboratory, Universiti Kebangsaan Malaysia Hospital, 9th floor, Clinical Block, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia;(3) BK-21 Polymer BIN Fusion Research Team, Department of Polymer Science and Technology, Chonbuk National University, 664-14, Dukjin, 561-756 Jeonju, Seoul, Korea |
| Abstract: | BackgroundSynthetic- and naturally derived- biodegradable polymers have been widely used to construct scaffolds for cartilage tissue engineering. Poly(lactic-co-glycolic acid) (PLGA) are bioresorbable and biocompatible, rendering them as a promising tool for clinical application. To minimize cells lost during the seeding procedure, we used the natural polymer fibrin to immobilize cells and to provide homogenous cells distribution in PLGA scaffolds. We evaluated in vitro chondrogenesis of rabbit articular chondrocytes in PLGA scaffolds using fibrin as cell transplantation matrix. |
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