复方疮疡涂膜剂的制备工艺优选

目的:优化复方疮疡涂膜剂的提取方法和制备工艺.方法:以绿原酸含量为指标,以加水倍数、煎煮时间、醇沉浓度为考察因素,采用L9(34)正交试验法.制备工艺以成膜性和成膜外观为指标,单因素优选成膜基质和辅料.结果:经方差分析,从而筛选出最优工艺为A3B3C1.最优制备工艺为PVA17-8811 g,加入PEG-400 2 mL,浓缩药液42 mL,搅拌,浸泡1h,水浴加热溶解,加入95％乙醇42 mL,甘油2 mL,氮酮1 mL,尼泊金乙酯适量,搅匀.结论:该工艺的稳定性良好,绿原酸含量高,成膜性能、外观以及成膜时间均较理想,可以作为该制剂的最优提取工艺.

Optimization of Preparation Technology for Compound Abscess Plaster

Objective: To optimize extraction and preparation technology for compound abscess plaster. Method: Extraction technology has chosen the content of chlorogenic acid as index, multiple of added water,boiling time, concentration of alcohol precipitation were as test factors by L₉(3⁴)orthogonal test.Samples were determined by HPLC.Preparation technology has chosen film-forming and film appearance as index, and taken One-factor test to find out optimum film-coating agent and accessories. Result: Optimum extraction technology was A₃B₃C₁.Optimal preparation technology was PVA-178 811 g, PEG-4 002 mL,concentrated liquid 42 mL,stired,soaked 1 h, dissolved in hot water,then added 42 mL 95% ethanol, 2 mL glycerol, 1 mL azone,amount of ethylparaben,stired well. Conclusion: This technology was stable with high content of chlorogenic acid. It was compatible in film-forming, appearance and film forming time. This technology could be chosen as optimum extraction technology.