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| 肝炎患者血清TT病毒核酸检测及分析 | |
| 引用本文： | 阎惠平,周育森,鲁文清,罗朝霞,郎振为,黄德庄,贺立香,王海涛. 肝炎患者血清TT病毒核酸检测及分析[J]. 天津医药, 2000, 28(2): 80-82 |
| 作者姓名： | 阎惠平 周育森 鲁文清 罗朝霞 郎振为 黄德庄 贺立香 王海涛 |
| 作者单位： | 1. 100054,北京佑安医院及北京市肝炎研究所 2. 军事医学科学院五所 3. 广西省南宁市第四人民医院 |
| 摘 要： | 目的：证实在不明原因的肝炎患者血清中一种新型病毒（ＴＴＶ）在存在，分析其感染特征。方法：用地高辛素标记基因探针，斑点杂交法检测未知和已知病原的肝炎患者７５例，正常对照１７例。结果：９２例血清ＴＴＶ ＤＮＡ总检出率为２３．９１％（２２/９２）。其中非甲～非戊型肝炎病人组检出率为３５％（７/２０），甲～戊肝组２１．８１％（２/５），肝硬化中１５．７９％（３/１９）。结论：ＴＴ病毒可能是导致病毒性肝炎的一种 |
| 关 键 词： | 病毒性肝炎 肝炎 ＴＴ病毒 核酸 DNA |
Detection and Analysis of Transfusion Transmitted Virus (TTV) DNA in Patients with Hepatitis |
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| YAN Huiping,ZHOU Yusen,LU Wenqing,et al. Detection and Analysis of Transfusion Transmitted Virus (TTV) DNA in Patients with Hepatitis[J]. Tianjin Medical Journal, 2000, 28(2): 80-82 | |
| Authors: | YAN Huiping ZHOU Yusen LU Wenqing et al |
| Affiliation: | YAN Huiping,ZHOU Yusen,LU Wenqing,et al;(Beijing You An Hospital, Beijing 100054) |
| Abstract: | Objective:To demonstrate the existence of a novel virus (transfusion transmitted virus,TTV) in patients with hepatitis,and to analyse its infectional feature. Methods:Using digoxigenin-labeled probe,75 sera of known or unknown etiology, and 17 blood donors were detected by dot blot hybridization. Results:The prevalence of TTV DNA was 23.91 % (22/92). Among them the positive rate of TTV DNA in the group without HAV~HEV was 35% (7/20),in the group with HAV ~HEV21.81% (12/55),in the blood donors 17.65% (3/17);in acute hepatitis 36.84% (7/19),in chronic hepatitis 21.88% (7/32), in severe hepatitis 40% (2/5) and in liver cirrhosis 15.79% (3/19). Conclusion:TT virus is a novel pos-sible virus which leads to hepatitis. This virus may occur single or superinfection, even be seen in blood donors. Acute and chronic infection, even severe liver injury may be present. |
| Keywords: | hepatitis viral human hepatitis viruses hybridization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |