左乙拉西坦佐治儿童难治性癫痫的疗效

目的探讨左乙拉西坦（LEV）佐治儿童难治性癫痫的临床疗效。方法选择2009年2月至2013年3月新乡医学院第三附属医院收治的难治性癫痫患儿58例，在对其行常规抗癫痫药物治疗基础上加用LEV进行佐治，并对佐治前后患儿癫痫的发作频次行Poisson回归分析。结果本组58例难治性癫痫患儿经LEV佐治，临床总有效率为74．1％（43／58），不同类型癫痫患儿的疗效比较差异无统计学意义（P〉0．05）；行LEV佐治后综合所有类型癫痫患儿情况，其总体发作频次减少率为42．5％，癫痫发作频次佐治前后比较差异有统计学意义（P〈0．01）；本组患儿7例有轻微不良反应，均能耐受。结论LEV佐治儿童难治性癫痫临床疗效满意，且不良反应轻微，患儿治疗耐受度良好，在传统抗癫痫药物较大程度失效时可加用LEV佐治。

Clinical effect of adjunctive levetiracetam therapy on children with refractory epilepsy

Objective To investigate the clinical effect of adjunctive levetiracetam（LEV） therapy on children with re- fractory epilepsy. Methods A total of 58 children with intractable epilepsy were selected from February 2009 to March 2013 in the Third Affiliated Hospital of Xinxiang Medical University. Based on their routine antiepileptic drug therapy, the adjunctive LEV therapy was added and the seizures frequency of the patients before and after the adjunctive LEV therapy were made Pois- son regression analysis. Results The clinical total effective rate was 74.1% （43/58） after the 58 patients had adjunctive LEV therapy and there was no significant difference among the different types of epilepsy patients（P 〉0.05）. The slip of total sei- zure frequency was 42.5% after all the patients had adjunctive LEV therapy,which was significantly decreased than that before adjunctive LEV therapy （P 〈 0.01 ）. Seven patients had a little untoward reaction and could tolerate them. Conclusions Ad- junctive LEV therapy on children with intractable epilepsy has satisfactory clinical efficacy, and little untoward reaction, and the patients have good tolerance degree. Adjunctive LEV therapy can be used for children with refractory epilepsy when the tradi- tional anti-epileptic drugs treatment failure.