基于功能CT成像对比剂团注方法的优化与仿真

背景：功能CT技术的出现使得在传统CT设备上实现同时同台的形态及功能成像成为了可能。目的：从对比剂团注方法着手，寻找一种在临床上比较合理的最优化功能CT成像的方法。方法：利用计算机仿真技术对从医院临床上得到的功能CT图像数据集进行仿真实验，研究对比剂的团注方法，单脉冲和多脉冲团注法与功能成像之间的关系，对仿真结果进行统计误差分析，从而找出在临床上可实用的最佳的对比剂团注方法。结果与结论：使用对脉冲团注对比剂比使用单脉冲团注对比剂对减低血流参数，毛细血管表面渗透参数和平均通过时间参数的不确定性有帮助；实验结果显示，多脉冲团注主要是双脉冲和三脉冲团注，其中使用双脉冲团注，相对参照值，血流参数和毛细血管表面渗透参数分别得到了36.9%和30.0%的改善，使用三脉冲团注相对双脉冲团注在个别生理参数上有一定程度的改善，但是其改善不是特别的明显。因此在临床实践中，使用双脉冲团注即可。

Simulation and optimization of functional CT imaging based on bolus injection of contrast medium

BACKGROUND: Functional CT technology allows morphological and functional imaging simultaneous on the same stage by the traditional CT device.OBJECTIVE: To search a reasonable clinical method to optimize CT imaging using contrast agent bolus injection method.METHODS: Using computer simulation technology, simulation experiment was performed using clinical CT image data from the hospital functions to study the contrast agent bolus injection method (single pulse and multiple pulse bolus injection) and the relationship between functional imaging. The simulation results were subjected to statistical error analysis to identify the best method of clinically useful contrast agent bolus. RESULTS AND CONCLUSION: Pulse bolus injection of contrast medium was better to reduce the blood flow parameters and benefit capillary permeability surface parameters and mean transit time parameter uncertainty compared with a single bolus injection of contrast medium on the pulse. Multi-pulse group involves a two-pulse and three pulse bolus injection, in which the use of double pulse bolus injection improved the relative reference values, 36.9% blood parameters and 30% capillary surface permeability parameter respectively. Three-pulse group exhibited a certain degree of improvement in individual physiological parameters compared with double-pulse bolus injection, but the improvement is not particularly clear. Therefore, double pulse bolus injection can be used in clinical practice.