Type of vascular invasion in association with progress of endometrial cancer |
| |
Authors: | Nicole C.M. Visser Henrica M.J. Werner Camilla Krakstad Karen K. Mauland Jone Trovik Leon F.A.G. Massuger Iris D. Nagtegaal Johanna M.A. Pijnenborg Johan Bulten Ingunn M. Stefansson |
| |
Affiliation: | 1. Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands;2. Center for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway;3. Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway;4. Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands;5. Department of Clinical medicine, Section 6. for Pathology, Haukeland University Hospital, Bergen, Norway;7. Center for Cancer Biomarkers, Department of Clinical Medicine, Section 8. for Pathology, University of Bergen, Bergen, Norway |
| |
Abstract: | Vascular invasion (VI) is a well‐established marker for lymph node metastasis and outcome in endometrial cancer. Our study explored whether specific types of VI, defined as lymphatic (LVI) or blood vessel invasion (BVI), predict pattern of metastasis. From a prospectively collected cohort, we conducted a case–control study by selecting three groups of endometrial cancer patients (n = 183): 52 with positive lymph nodes at primary surgery, 33 with negative nodes at primary surgery and later recurrence and death from disease, and 98 with negative nodes and no recurrence. All patients underwent hysterectomy with lymphadenectomy. Immunohistochemical staining with D2‐40 and CD31 antibodies was used to differentiate between BVI and LVI. By immunohistochemical staining, detection of VI increased from 24.6 to 36.1% of the cases. LVSI was significantly more often seen in patients with positive lymph nodes compared with patients with negative nodes (p = 0.001). BVI was significantly more often seen in node‐negative patients with recurrence compared with node‐negative patients without recurrence (p = 0.011). In multivariable analysis, BVI, age, and tumor grade were predictors separating patients with and without recurrence. Lymph node–positive patients showed more often LVI compared with lymph node–negative patients, while BVI seems to be a predictor for recurrent disease. |
| |
Keywords: | Endometrial cancer vascular invasion immunohistochemistry lymph node metastasis distant metastasis |
|
|