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Blocking effects of siRNA on VEGF expression in human colorectal cancer cells |
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| Authors: | Yu Yin Li-Yu Cao Wen-Qing Wu Hao Li Yan Jiang Hong-Fu Zhang |
| Institution: | Yu Yin, Li-Yu Cao, Wen-Qing Wu, Hao Li, Yan Jiang, Hong-Fu Zhang, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, ChinaWen-Qing Wu, Department of Pathology, Anhui Provincial Hospital, Hefei 230001, Anhui Province, China |
| Abstract: | AIM:To investigate the expression of vascular endothelial cell growth factor (VEGF) and its receptors Fmslike tyrosine kinase 1 (FLT-1) and fetal liver kinase 1 (FLK-1) in colorectal carcinoma (CRC),and the blocking effects of small interfering RNAs (siRNAs) on VEGF expression in human colorectal cancer HCT116 cells.METHODS:Immunohistochemical staining for VEGF,FLT-1 and FLK-1 proteins was performed in 82 cases of CRC and 14 normal colorectal mucosae.A siRNA targeting VEGF was synthesized and transfected in... |
| Keywords: | Colorectal carcinoma Vascular endothelial cell growth factor Fms-like tyrosine kinase 1 Fetal liver kinase 1 Small interfering RNA |
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