Isolation and radiation hybrid mapping of a dinucleotide repeat polymorphism at the human calcium-sensing receptor (CASR) locus |
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| Authors: | Kazuhiro Tsukamoto Ikuyo Watanabe Tadayoshi Shiba M Emi |
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| Institution: | (1) Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan Tel. +81-44-733-5230; Fax +81-44-733-5192 e-mail: memi@nms.ac.jp., JP;(2) Department of Molecular Biology, Faculty of Science, Kitasato University, Sagamihara, Japan, JP |
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| Abstract: | Calcium-sensing receptor (CASR) in parathyroid gland regulates calcium homeostasis by sensing decreases in extracellular
calcium levels and effecting an increase in secretion of parathyroid hormone. A polymorphic dinucleotide (CA) sequence was
isolated from a genomic clone containing the human CASR gene and was mapped to 3q13.3–q21. This polymorphism will be useful in the genetic study of disorders affecting calcium metabolism,
such as hypercalcemia, hypocalcemia, osteoporosis, hyperparathyroidism, and hypoparathyroidism.
Received: June 2, 1998 / Accepted: June 24, 1998 |
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| Keywords: | Calcium-sensing receptor parathyroid gland Calcium metabolism dinucleotide repeat |
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