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Genome‐wide association analysis accounting for environmental factors through propensity‐score matching: Application to stressful live events in major depressive disorder
Authors:Robert A. Power  Sarah Cohen‐Woods  Mandy Y. Ng  Amy W. Butler  Nick Craddock  Ania Korszun  Lisa Jones  Ian Jones  Michael Gill  John P. Rice  Wolfgang Maier  Astrid Zobel  Ole Mors  Anna Placentino  Marcella Rietschel  Katherine J. Aitchison  Federica Tozzi  Pierandrea Muglia  Gerome Breen  Anne E. Farmer  Peter McGuffin  Cathryn M. Lewis  Rudolf Uher
Affiliation:1. MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, , London, United Kingdom;2. Discipline of Psychiatry, School of Medicine, University of Adelaide, , Adelaide, SA 5005 Australia;3. Department of Psychiatry, University of Hong Kong, , Hong Kong, Special Administrative Region, China;4. MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, , Cardiff, United Kingdom;5. Barts and The London Medical School, Queen Mary University of London, , London, United Kingdom;6. Department of Psychiatry, School of Clinical & Experimental Medicine, University of Birmingham, , Birmingham, United Kingdom;7. Department of Psychiatry, Trinity Centre for Health Science, , Dublin, Ireland;8. Department of Psychiatry, Washington University, , St. Louis, Missouri;9. Department of Psychiatry, University of Bonn, , Bonn, Germany;10. Centre for Psychiatric Research, Aarhus University Hospital, , Risskov, Denmark;11. UOP 23‐Department of Mental Health, Spedali Civili Hospital and Biological Psychiatry Unit‐Centro San Giovanni di Dio, , FBF, Brescia, Italy;12. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, , Mannheim, Germany;13. GlaxoSmithKline Research & Development, , Verona, Italy;14. Department of Psychiatry, University of Toronto, , Toronto, Canada;15. NeuroSearch A/S, , Ballerup, Denmark;16. NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, , London, United Kingdom;17. Department of Psychiatry, Dalhousie University, , Halifax, NS, Canada
Abstract:
Keywords:depression  propensity score matching  stressful life events  genome‐wide association studies  gene–  environment interactions
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