The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration to man |
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Authors: | M.W. Sauerhoff W.H. Braun G.E. Blau P.J. Gehring |
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Affiliation: | 1. Health and Environmental Research, The Dow Chemical Co., Midland, Michigan 48640, U.S.A.;7. Computation Laboratory, The Dow Chemical Co., Midland, Michigan 48640, U.S.A. |
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Abstract: | The pharmacokinetic profile of 2,4-D is defined in man. Five male human volunteers ingested a single dose of 5 mg/kg 2,4-D without detectable clinical effects. Concentration of 2,4-D were determined in plasma in 3 of 5 subjects and in urine in all subjects at intervals after ingestion. The elimination of 2,4-D from plasma in all subjects occurred by an apparent first-order rate process with an average half-life () of 11.6 h. All subjects excreted 2,4-D in the urine with an average of 17.7 h. Excretion occurred mainly as 2,4-D (82.3%) with smaller amounts excreted as a 2,4-D conjugate (12.8%). Essentially all of the 2,4-D was absorbed from the gastrointestinal tract in man. Clearance of 2,4-D from the plasma and excretion from the body are first-order rate processes. There was no evidence that 2,4-D would accumulate following repeated administration. |
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Keywords: | 2,4-D 2,4-dichlorophenoxyacetic acid |
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