| 血浆孤啡肽水平与抑郁障碍的相关性研究 |
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| 引用本文： | 王丽娜,刘兰芬,乔冬冬,张敬悬. 血浆孤啡肽水平与抑郁障碍的相关性研究[J]. 精神医学杂志, 2008, 21(6): 401-402 |
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| 作者姓名： | 王丽娜 刘兰芬 乔冬冬 张敬悬 |
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| 作者单位： | [1]山东大学医学院,济南250012 [2]山东省精神卫生中心,济南250012 |
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| 基金项目： | 山东省卫生厅科研基金资助项目 |
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| 摘 要： | 目的探讨抑郁障碍患者血浆孤啡肽（OFQ）水平的变化。方法应用放射免疫（RIA）法分别测定24例抑郁患者和31例正常人血浆OFQ的浓度。结果 1．与对照组相比，抑郁组血浆OFQ水平明显增高（t=2．76，P〈0．01），差异有统计学意义。2．抑郁组0FQ含量与HAMD、MADRS总分呈显著正相关（P〈0．01）。结论血浆OFQ水平的变化可能参与抑郁障碍的发病机制，并可能提示病情的严重程度。
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| 关 键 词： | 抑郁障碍 孤啡肽 |
Relationship between plasma orphanin FQ and major depressive disorder |
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| WANG Lina,LIU Lanfen,QIAO Dongdong,et al.. Relationship between plasma orphanin FQ and major depressive disorder[J]. Journal of Psychiatry, 2008, 21(6): 401-402 |
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| Authors: | WANG Lina LIU Lanfen QIAO Dongdong et al. |
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| Affiliation: | WANG Lina,LIU Lanfen,QIAO Dongdong,et al. Medical College of Sh,ong University,Jinan 250012,China |
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| Abstract: | Objective To explore the relationship between plasma orphanin FQ (QFD)level and major depressive disorder. Methods The plasma concentrations of OFQ in 24 patients with major depressive disorder(MD group) and 31 health adults (control group) were measured by radioimmunoassay(RIA). Results 1.Compared with the control group, the level of plasma OFQ was significantly higher in MD group(t=2.76,P<0.01). 2.The plasma OFQ level was positively correlated to total scores of HAMD and MADRS(P<0.01). Conclusion The chan... |
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| Keywords: | Depressive disorder major Orphanin FQ |
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