血、尿核黄素水平与肺癌危险性的嵌套病例-对照研究

用 1∶2配比的嵌套病例 -对照设计研究了云锡矿工血、尿核黄素水平与肺癌危险性的关系。病例为云锡肺癌高危人群普查队列中 1992～ 1995年新确诊的肺癌患者 ,对照以 1:2的比例从普查队列的非肺癌矿工中随机抽取 ,按职业暴露史、年龄、血、尿样本采集时间等因素与病例配对 ,所测生化指标为红细胞谷胱甘酞还原酶活性系数 (EGR AC)和尿核黄素 肌酐比值。在调整了混杂因素的影响后 ,两项指标以连续变量引入logistic回归方程 ,其OR值分别为 0 780 (EGR AC)和 1 0 0 0 ,均无显著意义 (P >0 0 5) ;以等级变量将两项指标引入方程 ,两指标各等级的OR值也无显著性意义 (P >0 0 5)。本研究没有观察到血、尿核黄素水平与云锡矿工肺癌危险性有相关关系

Nested case-control study on riboflavin levels in blood and urine and the risk of lung cancer

The present study is designed to explore the relationship between the riboflavin levels in blood and urine and the risk of lung cancer among miners in Yunnan Tin Corporation(YTC)by means of nested case-control design. Cases we r e patients with lung cancer newly diagnosed from 1992 to 1995. For each case, 2 controls were randomly matched with occupational exposure history, age, the time of collecting blood or urine samples. The indexes for evaluating the riboflavin nutritional status were erythrocyte glutathione reductase activation coefficien t (EGR-AC) and the ratio of riboflavin and creatinine in urine.When analyzed a s either the continuous or the rank variables, the odds ratios(ORs) used to estim ate the relative risk of lung cancer have no statistical significance( P >0.05 ) af ter adjusting the confusing factors.No association of riboflavin indexes in blo od and urine with the lung cancer risk among YTC miners were observed in the pr esent study.