| 中期因子与胃癌的相关性研究现状 |
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| 引用本文： | 赵志强,卢辉山.中期因子与胃癌的相关性研究现状[J].医学综述,2008,14(18):2766-2768. |
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| 作者姓名： | 赵志强 卢辉山 |
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| 作者单位： | 福建医科大学附属协和医院肿瘤科,福州,350001 |
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| 摘 要： | 中期因子(MK)作为肝素结合生长因子家族的一员,通过促有丝分裂和细胞增殖、促血管生成、诱导细胞恶性转化、抗凋亡等功能影响胃癌细胞的增殖、分化及凋亡。MK在胃癌中呈过表达,且血清MK水平与预后不良相关,因此,MK有望成为一种新的肿瘤标志物;随着RNA干涉及特异性启动子参与基因治疗技术的发展,MK可能成为肿瘤基因治疗的新靶点,本文就MK与胃癌的关系进行综述。
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| 关 键 词： | 中期因子 肝素结合生长因子 肿瘤标志物 基因治疗 |
The Research Status Quo of the Dependablity between Midkine and Gastric Cancer |
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| ZHAO Zhi-qiang,LU Hui-shan.The Research Status Quo of the Dependablity between Midkine and Gastric Cancer[J].Medical Recapitulate,2008,14(18):2766-2768. |
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| Authors: | ZHAO Zhi-qiang LU Hui-shan |
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| Institution: | ZHAO Zhi-qiang,LU Hui-shan.(The Department of Oncology,the Union Hospital Affiliated Fujian Medical University,Fuzhou 350001,China) |
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| Abstract: | Midkine(MK),a heparin-binding growth factor,can regulate cell growth,survival and differentiation.MK is over-expressed in gastric cancer.And the serum midkine concentration is associated with prognosis.It may serve as a useful marker in the clinical follow-up of tumor.With the development of siRNA,MK may be developed as an effective anti-tumor agent.The relation between MK and gastric cancer is reviewed. |
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| Keywords: | Midkine Heparin-binding growth factor Tumor marker Gene therapy |
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