| 超额自由能估算药物在混合溶剂的溶解度研究 |
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| 引用本文： | 李焕文,梁月迎. 超额自由能估算药物在混合溶剂的溶解度研究[J]. 广东药学院学报, 1988, 0(1) |
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| 作者姓名： | 李焕文 梁月迎 |
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| 作者单位： | 广东医药学院物理化学教研室，广东医药学院物理化学教研室 |
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| 摘 要： | 应用超额自由能模型推导出溶解度方程,用来计算巴比妥(C8H_(12)N_2O_3)在乙醇一水混合溶的溶解度和扑热息痛(C8H9NO_2)在丙二醇-水混合溶剂的溶解度。本报告采用改进的实验方法获得实验结果表明该溶解度方程描述这些体系的溶解度是令人满意的。
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| 关 键 词： | 超额自由能 溶解度 混合溶剂 |
ECESS FREE ENERGY APPROACH TO THE ESTIMATION OF SOLUBILITY OF DRUGS IN MIXED SOLVENT SYSTEMS |
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| Lee HuanWen. ECESS FREE ENERGY APPROACH TO THE ESTIMATION OF SOLUBILITY OF DRUGS IN MIXED SOLVENT SYSTEMS[J]. Academic Journal of Guangdong College of Pharmacy, 1988, 0(1) |
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| Authors: | Lee HuanWen |
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| Affiliation: | Lee HuanWen Department of Physical Chemistry Guangdong Medical & Pharmceutical College |
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| Abstract: | The solubility equation derived from the excess free energy moder is used to describe the solubility of barbltal(C_8H_(12)N_2O_3)in eithanol-water mixtures and solubility of acetaminophen (C_8H_9NO_2); n propylene glycolwater mixtures. In this report, we used the improved experimental method to acquiretd he A_(1,3),A_(3,1) and C_2 term. The result of the experiment indicated that the quation describes solubility in these systems satifactorily. |
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| Keywords: | Excess free energy Solubility Mixed solvent |
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