心包积液患者心包液中CGRP和内皮素水平与积液量和心功能有关

目的 探讨心包积液患者心包液中降钙素基因相关肽（CGRP）、内皮素（ET-1）与积液量、心功能的关系。方法 35例心包积液患者按NYHA标准分为心功能Ⅲ、Ⅳ级，行超声心动图检查，计算积液量。行经皮穿刺心包腔内留置导管引流术时，取心包液及静脉血。正常对照组（血浆）30例。用放射免疫分析法测定心包液和血浆中CGRP、ET-1的浓度。 结果 心包液CGRP、ET-1的浓度显著高于血浆中的浓度（P<0.01），血浆中CGRP、ET-1含量较正常对照组明显升高（P<0.01），且心包液和血浆中CGRP、ET-1水平均与心功能相关（分别为P<0.01和P<0.05），心包液中CGRP、ET-1浓度与积液量呈正相关（分别为r=0.43、r=0.38，P<0.05）。结论 心包积液患者心包液中CGRP、ET-1的浓度与心功能、积液量密切相关。

Study of CGRP and ET-1 in pericardiac fluid of patients with pericardiac effusion

AIM To investigate the relationship between cardiac function, volume of pericardiac fluid (PF) and ET-1 and CGRP in the PF of patients with pericardiac effusion. METHODS The volume of PF was measured by echocariography in 35 patients with pericardiac effusion (NYHA class Ⅲ, Ⅳ). ET-1 and CGRP levels in PF and serum were detected by RIA and compared with those in serum in 30 healthy subjects. RESULTS Both ET-1 and CGRP levels in PF were significantly higher than those in serum (P<0.01) in patients with pericardiac effusion and the serum ET-1 and CGRP levels in patents with pericardiac effusion were significantly higher than those in control group. ET-1 and CGRP levels in PF and serum were related to the cardiac function (P<0.01, P<0.05, respectively). ET-1 and CGRP levels were positively related to the volume of PF (r=0.43, 0.38, respectively, P<0.05). CONCLUSION ET-1 and CGRP levels in PF are closely related to the cardiac function and the volume of PF in patients with pericardiac effusion.