Clinicopathological characteristics and prognosis of rectal well-differentiated neuroendocrine tumors |
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Authors: | Shunsuke Tsukamoto Shin Fujita Tomohiro Yamaguchi Seiichiro Yamamoto Takayuki Akasu Yoshihiro Moriya Hirokazu Taniguchi Tadakazu Shimoda |
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Institution: | (1) Department of Surgery, National Cancer Center Hospital, Shin Fujita, Tokyo, Japan;(2) Clinical Laboratory Division, National Cancer Center Hospital, Shin Fujita, Tokyo, Japan;(3) 1-1 Tsukiji 5-chome, Chuo-ku Tokyo, 104-0045, Japan |
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Abstract: | Background To clarify the oncological outcome of rectal well-differentiated neuroendocrine tumors (W/D NETs), we examined the clinicopathological
characteristics and prognosis of patients with this neoplasm.
Materials and methods A total of 23 patients who underwent surgical treatment with lymph node dissection for rectal W/D NETs between 1973 and 2007
were reviewed.
Results Median tumor size measured preoperatively was 13 mm (range, 4–25 mm), and the median number of dissected lymph nodes was 16
(range, 1–46). The incidence of lymph node metastasis was 61% (14 of 23 cases). The smallest W/D NETs with lymph node metastasis
was 10 mm in diameter. All the patients without lymph node metastasis survived without recurrence. Among 11 patients who had
only regional lymph node metastasis, only one developed liver metastasis and died 13 months after initial surgery. Among three
patients with lateral pelvic lymph node metastasis, two survived more than 5 years, although two had liver metastasis.
Conclusions Because the incidence of lymph node metastasis is very high in patients with rectal W/D NETs greater than 10 mm in diameter,
radical surgery is required. In this series, the outcome of rectal W/D NETs patients with lateral pelvic lymph node metastasis
was better than expected. |
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Keywords: | Neuroendocrine tumors Rectum Lateral pelvic lymph node Lymph node metastasis |
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