阿米迪治疗儿童肺炎支原体感染后持续性咳嗽的临床研究

目的 观察并分析阿米迪治疗肺炎支原体感染持续性咳嗽的临床疗效.方法 以2014年1月至2015年2月本院收治的肺炎支原体感染后咳嗽患儿98例为研究对象,随机分为两组,每组49例.两组均按支原体肺炎的常规方法治疗,研究组加用阿米迪贴剂治疗.观察并比较两组咳嗽减轻的有效率、治愈率、肺功能(PEF)及外周血嗜酸性粒细胞(EOS)的计数数量.结果 治疗组第7、15、22 d的咳嗽症状减轻有效率分别为67.34％,81.63％、89.80％,高于对照组的34.69％、57.14％、65.31％,差异均有统计学意义(均P＜ 0.05);治疗组第22 d时治愈率为75.59％,高于对照组的59.18％,差异有统计学意义(P＜0.05).治疗组PEF治疗后高于治疗前f(3.381±0.436)比(2.795±0.432)],差异有统计学意义(P＜0.05);治疗组EOS计数数量治疗后低于治疗前[(408.7±22.4)比(592±48.3)],差异有统计学意义(P＜0.05).结论 阿米迪贴剂治疗肺炎支原体感染后咳嗽,方便有效,副作用小,值得临床推广和应用.

Clinical study of Amidi in the treatment of persistent cough after mycoplasma pneumoniae infection

Objective To observe and analyze the clinical effect of Amidi in the treatment of persistent cough after mycoplasma pneumoniae infection.Methods In this study,98 pediatric patients with persistent cough after mycoplasma pneumoniae infection treated in our hospital from January 2014 to February 2015 were randomly divided into the treatment group (49 cases) and the control group (49 cases).The patients of the two groups were treated by routine therapy for mycoplasma pneumonia,and the treatment group was treated by Amidi on the basis.The following indexes,including the effective rate,the cure rate,pulmonary function (PEF),and the count of peripheral blood eosinophil (EOS) were observed and compared between the two groups.Results The cough symptom decreased effective rate in the treatment group on the 7th,15th,22nd day were 67.34％,81.63％,89.80％,higher than 34.69％,57.14％,65.31％ in the control group,with statistically significant differences (P＜0.05).The cure rate in the treatment group on the 22nd day was 75.59％,higher than 59.18％ in the control group,with statistically significant difference (P＜0.05).PEF after the treatment in the treatment group was significantly higher than that before the treatment [(3.381+0.436) vs.(2.795±0.432)],with statistically significant difference (P＜0.05).The count of peripheral blood eosinphil after the treatment in the treatment group was significantly lower than that before the treatment [(408.7+22.4) vs.(592.0+48.3)],with statistically significant difference (P＜0.05).Conclusion Amidi has definite effect for persistent cough after mycoplasma pneumoniae infection,convenient and effective,worthy of promotion and application.