持续静脉滴氨茶碱联合异丙托溴铵治疗慢性阻塞性肺疾病急性加重期的临床研究

目的 研究持续静脉滴氨茶碱联合异丙托溴铵治疗慢性阻塞性肺疾病急性加重期的临床疗效.方法 在本院2016年1月至2016年12月收治的慢性阻塞性肺疾病急性加重期患者中随机选择50例,将其随机分为观察组及对照组,各25例.观察组持续静脉滴氨茶碱联合异丙托溴铵治疗,对照组单用异丙托溴铵治疗,比较2种治疗方法治疗后FEV1/FVC(一秒钟用力呼气容积占用力肺活量百分比)、FEV1％(一秒钟用力呼气容积占预计值百分比),以及最终疗效.结果 持续静脉滴氨茶碱联合异丙托溴铵治疗效果96.00％明显高于单用异丙托溴铵治疗效果76.00％.治疗后,观察组FEV1/FVC及FEV1％指标好转情况优于单用异丙托溴铵治疗.结论 对慢性阻塞性肺疾病急性加重期患者,采取持续静脉滴氨茶碱联合异丙托溴铵治疗,可以使FEV1/FVC及FEV1％等相关指标好转,临床效果好.

Clinical study on continuous intravenous infusion of aminophylline combined with ipratropium bromide in the treatment of acute exacerbation of chronic obstructive pulmonary disease

Objective To study the clinical efficacy of continuous intravenous infusion of aminophylline combined with ipratropium bromide in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods Fifty patients with acute exacerbation of chronic obstructive pulmonary disease admitted in our hospital from January 2016 to December 2016 were randomly divided into observation group (n=25) and control group (n=25).The observation group was treated with continuous intravenous infusion ofaminophylline combined with ipratropium bromide,while the control group was only treated with ipratropium bromide.FEV1/ FVC (one-second forced expiratory volume occupying percentage of vital capacity),FEV1％ (one-second forced expiratory volume as a percentage of predicted value),and final outcome were compared between the two groups.Results The effect of continuous intravenous infusion of aminophylline combined with ipratropium bromide (96.00％) was significantly higher than that of ipratropium bromide alone (76.00％).After treatment,the improvement of FEV1/FVC and FEV1％ indexes in the observation group were better than those in the control group.Conclusion In the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease,continuous intravenous infusion of aminophylline combined with ipratropium bromide can improve FEV/FVC and FEV1％,with good clinical effect.