莫沙必利联合穴位注射对功能性消化不良患者近端胃舒张和胃排空功能的影响

目的 探讨莫沙必利片联合穴位注射对功能性消化不良(FD)患者近端胃舒张和胃排空功能的影响.方法 收集FD患者142例,随机分为对照组和联合组,每组71例.对照组给予枸橼酸莫沙必利片治疗,联合组在口服枸橼酸莫沙必利片治疗同时,给予穴位注射复方丹参注射液治疗.观察两组治疗前、后血清胃动素(MTL)、胃促生长素(Ghrelin)水平、胃底气体评分、胃排空率及饮水和显影剂后0、30、60 min时的近端胃容积变化,同时对比两组的临床疗效.结果 治疗后联合组的血清MTL、Ghrelin水平分别为(218.6±27.4) pg/ml、(3.8±1.6) ng/ml,明显高于对照组的(175.1±26.5) pg/ml、(3.2±1.5)ng/ml (P＜0.05);胃底气体评分为(0.4±0.2),明显低于对照组的(0.6±0.3);胃排空率为(75.8±19.4)％,明显高于对照组的(57.2±l6.6)％(P＜0.05);治疗后饮水和显影剂后60 min时,联合组近端胃容积为(12.4±4.6)ml,明显小于对照组的(22.6±5.2)ml(P＜0.05),联合组的显效率及总有效率分别为63.4％、87.3％,明显高于对照组的35.2％、63.4％ (P＜0.05).结论 枸橼酸莫沙必利片联合穴位注射能有效提高FD患者的MTL、Ghrelin水平,降低胃底气体评分,促进胃排空,改善近端胃舒张功能,提高临床疗效.

Effect of mosapride combined with acupoint injection on proximal gastric diastole and gastric emptying of patients with functional dyspepsia

Objective To investigate the effect of mosapride combined with acupoint injection on proximal gastric diastole and gastric emptying of patients with functional dyspepsia (FD).Methods 142 patients with FD were collected and were randomly divided into control group and combination group,71 cases in each group.The control group was treated with mosapride citrate tablets,and the combination group was given acupoint injection of Danshen injection and oral mosapride citrate tablets.The serum motilin (MTL),Ghrelin levels and stomach gas score,gastric emptying rate before and after treatment,and proximal gastric volume changes at 0 min,30 min,60 min after drinking water and developer were observed between the two groups.At the same time the clinical efficacy were compared between the two groups.Results The serum MTL,Ghrelin levels in the combination group after treatment were respectively (218.6±27.4)pg/ml,(3.8± 1.6)ng/ml,significantly higher than those in the control group (175.l±26.5)pg/ml,(3.2±1.5)ng/ml] (P＜0.05);the stomach gas score in the combination group was (0.4±0.2),obviously lower than that in the control group (0.6±0.3)];the gastric emptying rate in the combination group was (75.8±19.4)％,significantly higher than that in the control group (57.2±16.6)％] (P＜0.05);the proximal stomach volume in the combination group 60 min after drinking water and developer was (12.4±4.6)ml,which was significantly less than that in the control group (22.6±5.2)ml] (P＜0.05);the marked effective rate and total effective rate in the combination group were respectively 63.4％ and 87.3％,which were significantly higher than those in the control group (35.2％,63.4％) (P＜0.05).Conclusion Mosapride citrate tablets combined with acupoint injection can effectively improve the MTL and Ghrelin levels of patients with FD,reduce the stomach gas score,promote gastric emptying,improve proximal stomach diastolic function and clinical curative effect.