Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers |
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| Authors: | DG Evans S. Howel ER Woodward A. Howell F. Lalloo |
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| Affiliation: | 1.Manchester Centre for Genomic Medicine, Manchester Academic Health Sciences Centre (MAHSC), Institute of Human Development, St Mary’s Hospital,University of Manchester,Manchester,UK;2.Prevent Breast Cancer Centre,University Hospital of South Manchester NHS Trust,Wythenshawe,UK;3.Manchester Centre for Genomic Medicine, St Mary’s Hospital,Central Manchester University Hospitals NHS Foundation Trust,Manchester,UK;4.Manchester Breast Centre,The University of Manchester,Manchester,UK;5.Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre,University of Manchester,Manchester,UK;6.Department of Medical Oncology,The Christie,Manchester,UK |
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| Abstract: | PurposePrevious research assessing the impact of pregnancy and age at first pregnancy on breast cancer risk in BRCA1 and BRCA2 mutation carriers has produced conflicting results, with some studies showing an increased risk following early first pregnancy in contrast to the reduced risk in the general population of women. The present study addresses these inconsistencies.MethodsFemale BRCA1 and BRCA2 carriers from North West England were assessed for breast cancer incidence prior to 50 years of age comparing those with an early first full-term pregnancy (< 21 years) to those without a full-term pregnancy. Breast cancer incidence per decade from 20 years and Kaplan–Meier analyses were performed.Results2424 female mutation carriers (1278 BRCA1; 1146 BRCA2) developed 990 breast cancers under the age of 50 years. Women who had their first term pregnancy prior to age 21 (n = 441) had a lower cancer incidence especially between age 30–39 years. Kaplan–Meier analysis showed an odds ratio of 0.78 for BRCA1 (p = 0.005) and 0.73 for BRCA2 (p = 0.002).ConclusionsThe present study demonstrates a clear protective effect of early first pregnancy on breast cancer risk in both BRCA1 and BRCA2 mutation carriers. |
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