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Changes in Cell Characteristics Due to Culture Conditions in Cell Lines From Human Small Cell Lung Cancer |
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| Authors: | TERASAKI, TAKEO SHISMOSATO, YUKIO NAKAJIMA, TAKASHI TSUMURAYA, MASARU MORINAGA, SHOJIROH HIROHASHI, SETSUO YAMAGUCHI, KEN KATO, KANEFUSA ICHINOSR, HIROSHI NAGATSU, TOSHIHARU |
| Affiliation: | Pathology, National Cancer Center Research Institute Tokyo 1Endocrinology Divisions, National Cancer Center Research Institute Tokyo 2Department of Biochemistry, Institute for Developmental Research Aichi Prefectural Colony, Kasugai 3Department of Biochemistry,Nagoya University School of Medicine Nagoya |
| Abstract: | Eight cultured cell lines were established from human smallcell lung cancers. Every cell line showed the morphologicaland biochemical characteristics of small cell cancer. Changesin cell characteristics were observed in many of these celllines when culture conditions were changed: "oat cell type"changed to "intermediate cell type" and vice versa when serum-freemedium was changed to serum-supplemented medium; a deficiencyof vitamin A in the medium caused a change to squamous cellsand vice versa; and a tumor promoter (teleocidin B) enhancedthe adherence of these cells to the surface of plastic culturedishes. These findings provide evidence that many small celllung cancer cell lines can change their morphology with changesin the environment of the cells. |
| Keywords: | Small cell lung carcinoma Cell lines Morphology Vitamin A Telecidin B |
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