Oxidative damage in foundry workers occupationally co-exposed to PAHs and metals |
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| Authors: | Hung-Hsin Liu Ming-Hsiu Lin Chia-I Chan Hsiu-Ling Chen |
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| Affiliation: | 1. Department of Industrial Safety & Health, Hung Kuang University, Taichung, Taiwan;2. School of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan;3. Institute of Occupational Safety and Health, Council of Labor Affairs, Taipei, Taiwan |
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| Abstract: | Occupational exposure to polycyclic aromatic hydrocarbons (PAHs) has been reported in foundries. A higher risk for DNA damage or oxidative damage lesions was also found in occupationally PAH-exposed groups. The aim of this study was to assess PAH exposure by urinary excretion of 1-hydroxypyrene (1-OHP), a biological exposure marker. Furthermore, we aimed to evaluate the oxidative damage of foundry workers with different job tasks and the association between 1-OHP, metal exposure and oxidative damage in foundry workers exposed to pervasive carcinogens. |
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| Keywords: | PAHs 1-hydroxypyrene Metal 8-OH-dG DNA strand breakage MDA Foundry |
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