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Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos |
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| Authors: | Beate Pesch Dirk Taeger Georg Johnen Isabelle M Gross Daniel G Weber Monika Gube Alice Müller-Lux Evelyn Heinze Thorsten Wiethege Volker Neumann Andrea Tannapfel Hans-Jürgen Raithel Thomas Brüning Thomas Kraus |
| Institution: | 1. Center of Epidemiology, BGFA – Research Institute of Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum, Germany;2. Center of Molecular Medicine, BGFA – Research Institute of Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany;3. Core Center, BGFA – Research Institute of Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany;4. BGFA – Research Institute of Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany;5. Institute for Occupational and Social Medicine, RWTH Aachen, University Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany;6. Institute of Pathology, Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany;g Institute of Occupational, Social and Environmental Medicine, Friedrich Alexander University Erlangen-Nuremberg, Schillerstrasse 25 and 29, 91054 Erlangen, Germany |
| Abstract: | The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were calculated and Poisson regression was performed to assess mesothelioma risks. A high risk was observed for pleural mesothelioma (SMR 28.10, 95% CI 15.73-46.36) that decreased after cessation of exposure (RR 0.1; 95% CI 0.0–0.6 for ≥30 vs. <30 years after last exposure). Asbestosis was a significant risk factor for mesothelioma (RR 6.0, 95% CI 2.4-14.7). Mesothelioma mortality was still in excess in former asbestos workers although decreasing after cessation of exposure. Fibrosis was associated with subsequent malignancy. |
| Keywords: | Asbestos Asbestosis Surveillance Prospective cohort Mesothelioma Lung cancer |
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