| 对－取代苯甲酰氨基苯甲酸（甲酯）的合成及其分化诱导HL－60细胞活性试验 |
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| 引用本文： | 于保新,胥佩菱,曾昭贤. 对－取代苯甲酰氨基苯甲酸（甲酯）的合成及其分化诱导HL－60细胞活性试验[J]. 四川大学学报(医学版), 1994, 0(1) |
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| 作者姓名： | 于保新 胥佩菱 曾昭贤 |
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| 摘 要： | 作者合成了１６个对－苯甲酰氨基苯甲酸（甲酯），并进行了分化诱导人髓系白血病细胞（ＨＬ－６０细胞）的活性试验，其中有４个化合物活性较强，在浓度为１０￣（－６）ｍｏｌ／Ｌ时可使２５％～５０％以上的早幼粒细胞分化为较成熟细胞；有两个化合物在浓度为５×１０￣（－６）ｍｏｌ／Ｌ时可使细胞分化率提高到７０％，但较维Ａ酸分化率（９７％）为低。
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| 关 键 词： | 对－取代苯甲酰氨基苯甲酸，对－取代苯甲酰氨基苯甲酸衍生物，人髓系白血病细胞，抗癌活性，癌细胞的分化诱 |
Synthesis of p-Substituted Benzoylaminobenzoic Acid (Methyl Esters)and Its Differentiation Induction in Activities of Human Promyelocytic Leukemia Cells HL-60 |
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| Yu Baoxin,Xu Peiling,Zeng Zhaoxian. Synthesis of p-Substituted Benzoylaminobenzoic Acid (Methyl Esters)and Its Differentiation Induction in Activities of Human Promyelocytic Leukemia Cells HL-60[J]. Journal of Sichuan University. Medical science edition, 1994, 0(1) |
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| Authors: | Yu Baoxin Xu Peiling Zeng Zhaoxian |
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| Affiliation: | 1 Department of Orgain Chemistry School of Pharmacy 2.Department of Pharmcology School of Basic Medical Sciences |
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| Abstract: | Sixteen p-substituted benzoylaminobenoic acids and their metyl esters were synthesized of which nine were not found in literature All of the thpic compounds were evaluated for their differentia-tion indution in activities of human promyelotic |
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