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P53蛋白在胃癌中的表达分析
引用本文:何均辉,邹秀玲,李忠楚,陆忠奎.P53蛋白在胃癌中的表达分析[J].中国医药导报,2012,9(5):86+88-86,88.
作者姓名:何均辉  邹秀玲  李忠楚  陆忠奎
作者单位:1. 广东省佛山市顺德区大良医院内三科,广东佛山,528300
2. 广东省佛山市顺德区龙江医院肿瘤科,广东佛山,528318
3. 广东省佛山市顺德区龙江医院内三科,广东佛山,528318
4. 广东省佛山市顺德区龙江医院检验科,广东佛山,528318
摘    要:目的探讨P53蛋白在胃癌中的表达。方法胃癌患者53例作为A组,胃炎患者53例作为B组,健康人士53例作为C组,均采用免疫组织化学法(S-P)检测P53阳性率。结果 A组P53阳性率为64.2%,B组为32.1%,C组为13.2%,组间比较差异有统计学意义(A、B:χ2=9.674,P〈0.01;A、C:χ2=26.888,P〈0.01;B、C:χ2=4.363,P〈0.05)。A组高分化癌P53阳性率为78.6%,低分化癌为48.0%,两者比较差异有统计学意义(χ2=4.120,P〈0.05)。B组浅表性胃炎P53阳性率为40.0%,萎缩性胃炎为21.7%,萎缩性胃炎P53阳性率高于浅表性胃炎,但差异无统计学意义(χ2=1.243,P〉0.05)。结论对胃病患者进行P53的早期检测,对监测病情和改善预后具有重要意义,值得临床考虑。

关 键 词:P53  胃癌  表达

Analysis on expression of positive rate of P53 protein in patients with gastric cancer
HE Junhui,ZOU Xiuling,LI Zhongchu,LU Zhongkui.Analysis on expression of positive rate of P53 protein in patients with gastric cancer[J].China Medical Herald,2012,9(5):86+88-86,88.
Authors:HE Junhui  ZOU Xiuling  LI Zhongchu  LU Zhongkui
Institution:1.The Third Department of Medical,Daliang Hospital of Shunde District in Foshan City,Guangdong Province,Foshan 528300,China;2.Department of Oncology,Longjiang Hospital of Shunde District in Foshan City,Guangdong Province,Foshan 528318,China;3.The Third Department of Medical,Longjiang Hospital in Shunde District in Foshan City,Guangdong Province,Foshan 528318,China;4.Department of Laboratory,Longjiang Hospital of Shunde District in Foshan City,Guangdong Province,Foshan 528318,China
Abstract:Objective To study the expression of positive rate of P53 protein in patients with gastric cancer.Methods 53 cases of patients with gastric cancer as group A,53 cases of patients with gastritis as group B and 53 cases of healthy person as group C were all given detection of positive rate of P53 by S-P method.Results The positive rate of P53 in group A was 78.6%;group B was 48.0%;group C was 13.2%.There were significant difference’s between each group(A,B: χ2=9.674,P<0.01;A,C: χ2=26.888,P<0.01;B,C: χ2=4.363,P<0.05).The positive rate of P53 in group A of differentiated carcinoma was 78.6%;poor differentiated carcinoma was 48.0%.The comparison between the two showed significant difference(χ2=4.120,P<0.05).The positive rate of P53 in group B of superficial gastritis was 40.0%;atrophic gastritis was 21.7%.The superficial gastritis was higher,but no significant difference(χ2=1.243,P >0.05).Conclusion Detection of P53 of patients with gastropathy at early stage is very important on monitoring disease and changing prognosis,so it deserves considering in clinical work.
Keywords:P53  Gastric cancer  Expression
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