循环内皮祖细胞与急性脑梗死及脑血管病危险因素的相关性研究

目的探讨循环内皮祖细胞（EPC）数量和急性脑梗死及脑血管危险因素的关系。方法以CD133和KDR双阳性细胞作为EPC标记,用流式细胞仪对145例急性脑梗死患者（脑梗死组）、118例脑血管危险因素患者（危险因素组）和99例健康志愿者（对照组）的外周血EPC数量进行检测。结果与正常对照组比较,脑梗死组和危险因素组EPC数量明显减少（均P〈0.01）,脑梗死组EPC数量较危险因素组高,但差异无统计学意义（P=0.057 8）。脑梗死组和危险因素组EPC数量均与收缩压、舒张压、HbA1c、CHO、LDL-C水平呈显著负相关（均P〈0.05）,与HDL-C水平呈显著正相关（P〈0.05）,与年龄、TG水平无关（均P〉0.05）;循环EPC数量与NIHSS评分呈显著负相关（P〈0.05）。结论循环EPC数量与脑血管危险因素相关,其数量减少与急性脑梗死的病情严重程度明显相关,脑梗死可能会有限增加EPC的动员。

The correlation analysis beween the number of circulation endothelial progenitor cells and acute cerebral infarction and risk factors of cerebrovascular disease

Objective To analyze the correlation between the number of peripheral blood endothelial progenitor cells(EPCs) and acute cerebral infarction and risk factors of cerebrovascular disease.Methods The EPC was marked by CD133 and KDR.The number of peripheral blood EPCs of 145 patients with acute cerebral infarction(infarction group),118 patients with risk factors of cerebrovascular disease(risk factor group) and 99 health people(control group) were detected by flow cytometry.Results Compared with control group,the EPCs number of infarction group and risk factor group were decreased significantly(P<0.01).The EPCs number of infarction group was higher than that of risk factor group,but there was no significant difference(P=0.057 8).The EPCs number of infarction group and risk factor group had negative correlation with systolic blood pressure,diasolic blood pressure,glycosylated hemoglobin A1c(HbA1c),cholesterol(CHO),low density lipoprotein-cholesterol(LDL-C)(P<0.05),while which had positive correlation with high density lipoprotein-cholesterol(HDL-C)(P<0.05).The number of EPCs had no correlation with age and triglyceride(TG)(P>0.05).The number of EPCs had negative correlation with NIHSS scores(P<0.05).Conclusion The number of peripheral blood EPCs has correlation with the risk factors of cerebrovascular disease.The serious degree of acute cerebral infarction has correlation with the decreasing number of EPCs.Acute cerebral infarction can limited increase the mobilization of EPCs.