内脏伤害性刺激在脊髓突触后背柱神经元的信号转导机制

内脏痛是急慢性胃肠道、盆腔、泌尿道和其它实体器官疾病的最常见症状之一。许多疾病伴发的内脏性疼痛十分顽固,如肠道激惹综合征、间质性膀胱炎、胰腺炎、子宫内膜异位症和癌性内脏痛等,给临床医师带来了极大的挑战。内脏疼痛机制十分复杂。近年来,一系列的临床和基础研究发现起源于

Signaling transduction of noxious visceral stimuli in postsynaptic dorsal column neurons in spinal cord

The spinal postsynaptic dorsal column pathway plays a critical role in the visceral pain transmission in spinal cord.The noxious visceral stimuli might induce complex receptor expression and intracellular signaling transductions in postsynaptic dorsal column neurons.It has been demonstrated that neurokinin-1(NK-1) receptor,α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor(AMPAR),and intracellular protein kinase C(PKC),protein kinase A(PKA),mitogen-activated protein kinases(MAPKs) and cAMP response element-binding(CREB) protein are involved in the signaling transduction of visceral stimuli.All these processes contribute to the sensitization of postsynaptic dorsal column neurons and enhance the spinal transmission of visceral pain,indicating a potential and promising way of visceral pain therapy to inhibit the sensitization of postsynaptic dorsal column neurons.