| 金菊消痔栓的质量标准研究 |
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| 引用本文： | 陈瑾. 金菊消痔栓的质量标准研究[J]. 医药导报, 2012, 31(1): 79-81. DOI: 10.3870/yydb.2012.01.031 |
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| 作者姓名： | 陈瑾 |
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| 作者单位： | 四川省医学科学院、四川省人民医院药剂科,成都,610072 |
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| 摘 要： | 目的 建立金菊消痔栓的质量标准.方法 采用薄层色谱法鉴别金菊消痔栓中大黄、冰片;用高效液相色谱法对制剂中绿原酸进行定量分析.结果 定性鉴别大黄、冰片分离度好,专属性强;绿原酸的含量测定线性范围为5.4～108.8 μg (r＝0.999 9,n＝6),平均回收率为99.03% (RSD＝1.61%,n＝6).结论 该研究建立的方法准确可靠,灵敏度高,专属性强,可有效控制金菊消痔栓的质量.
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| 关 键 词： | 金菊消痔栓 绿原酸 质量标准 色谱法,高效液相 色谱法,薄层 |
Research of Quality Standard for Jinju Xiaozhi Suppository |
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| CHEN Jin. Research of Quality Standard for Jinju Xiaozhi Suppository[J]. Herald of Medicine, 2012, 31(1): 79-81. DOI: 10.3870/yydb.2012.01.031 |
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| Authors: | CHEN Jin |
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| Affiliation: | CHEN Jin(Department of Pharmacy,Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital,Chengdu 610072,China) |
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| Abstract: | Objective To establish the quality standard for jinju xiaozhi suppository.Methods Radix et Rhizoma Rhei and Borneolum in jinju xiaozhi suppository were identified by TLC(thin layer chromatograph).Chlorogenic acid was determined by HPLC.Results The characteristic identification by TLC was distinct and highly specific.The results of quantitative evaluation showed that chlorogenic acid had the linear range of 5.4-108.8 μg(r=0.999 9,n=6),and the average recovery was 99.03%(RSD=1.61%,n=6).Conclusion The method is reliable,accurate and specific,which is benefit for the quality control of jinju xiaozhi suppository. |
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| Keywords: | Jinju xiaozhi suppository Chlorogenic acid Quality standard HPLC TLC |
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