肝动脉节段性化疗栓塞治疗原发性肝癌36例临床分析

目的探讨经动脉化疗栓塞治疗原发性肝癌的临床途径、疗效及安全性。方法将72例原发性肝癌患者随机分为观察组和对照组,各36例。观察组实施节段性化疗栓塞治疗,对照组采用非节段化疗栓塞治疗。结果观察组总有效率为94.44%,对照组总有效率为66.67%,两组比较差异有高度统计学意义（P〈0.01）。两组1年期生存率比较差异有高度统计学意义（χ2=6.883,P〈0.01）,2年期生存率比较差异无统计学意义（χ2=1.143,P〉0.05）。治疗过程中,所有患者均出现程度不等的术后发热、右上腹疼痛、恶心、呕吐等,经3～7 d后逐渐消失。其中,观察组使用杜冷丁者5例（13.89%）,对照组24例（66.67%）。结论经肝动脉节段性化疗栓塞是治疗原发性肝癌的一种安全可靠、疗效明显的手段,其疗效及安全性明显优于非节段化疗栓塞,值得临床推广。

Clinical analysis of 36 cases on arterial segmental chemoembolization for primary hepatic carcinoma

Objective To investigate the clinical procedure,effect and safety of the transcatheter arterial segmental chemoembolization(TASCE) for primary hepatic carcinoma.Methods 72 cases of primary hepatic carcinoma(PHC) were randomly divided into observation group and control group,with 36 cases in each group.The observation group was given segmental chemoembolization,and the control group was given non-segmental chemoembolization.Results The overall efficient response rate was 94.44% in observation group and 66.67% in control group.The difference between the two groups was highly significant(P < 0.01).The one-year survival rate of the two groups had significant differences(χ2 = 6.883,P < 0.01),two-year survival rates of two groups had no significant difference(χ2 = 1.143,P > 0.05).During the treatment,all patients suffered from varying degrees of postoperative fever,right upper quadrant pain,nausea,vomiting,etc,all these were disappear after 3-7 d gradually.5 cases were injected Pethidine in the observation group(13.89%),24 cases were injected Pethidine in the control group(66.67%).Conclusion The treatment of transcatheter arterial segmental chemoembolization for primary hepatic carcinoma is a high efficient method with safe and reliable operation.Its efficient and safety are much better than the non-segmental chemoembolization and worthy of clinical promotion.