磁共振成像T2*WI观察大鼠自发性脑出血含铁病灶的演变过程

目的:旨在研究用MRI T2*WI检测自发性脑出血后含铁病灶的演变过程.方法:大鼠脑内注射不同体积的自体动脉血(A组10μL;B组50μL;C组100μL).各组术后第1、3,7,14和30天行脑部MRI T2WI和T2*WI扫描,记录图像特征.由Image J软件进行图像分析.结果:大鼠脑内注射自体血后,MRI T2*WI图像较T2WI明显清晰;A、B组大鼠术后7和14 d含铁病灶体积T2*WI较T2WI所测得的体积更大(P<0.05); C组大鼠术后第7、14和30天,T2*WI比较T2WI测得的体积也更大(P<0.05).结论:在自发性脑出血后含铁病灶的检测中,MRI T2*WI较MRI T2WI更为清晰和敏感.

The Detection of Iron-containing Lesions Using MRI T2*WI after Spontaneous Intracerebral Hemorrhage in Animal Experiments

Aim： To detect the iron-containing lesions using MRI GRE-T2＊WI after spontaneous intracerebral hemorrhage（SICH） in animal experiments.Methods： Rats received an injection of autologous blood（group A 10 μL;group B 50 μL and group C 100 μL）,1,3,7,14 and 30 days after the operation,rats were given MRI T2WI and T2＊WI scans around the needle area,MRI were recorded and analyzed by using Image J.Results： MR T2＊WI images of iron lesion were significantly more clear than T2WI.In group A and B,the lesion volume in T2＊WI images was larger than T2WI images 7 and 14 days after SICH（P0.05）.In group C,the lesion volume in T2＊WI images was larger than T2WI images 7,14 and 30 days after SICH（P0.05）.Conclusion： T2＊WI are more clear and sensitive than T2WI in the detection of iron lesion after SICH.