Clinical effects of date palm (Phoenix dactylifera L.): A systematic review on clinical trials |
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| Affiliation: | 1. Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;2. Department of Orthopedic Surgeries, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;3. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Midwifery Department, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;5. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran;1. Department of Midwifery, Graduate School, Hasanuddin University, Indonesia;2. Department of Pharmacy, Pharmacy Faculty, Hasanuddin University, Indonesia;3. Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Indonesia;1. Laboratory of Plant Biotechnology, Sfax Faculty of Sciences, PB 1171, University of Sfax, 3038 Sfax, Tunisia;2. Laboratory of Toxicology, Environmental Microbiology and Health, Sfax Faculty of Sciences, PB 1171, University of Sfax, 3038 Sfax, Tunisia;3. Electro-Chemical Environmental Laboratory, ENIS, BP 1173 Soukra Road, University of Sfax, Sfax 3038, Tunisia;1. Department of Molecular & Cellular Biology, Faculty of Biology, Damghan University, Semnan, Iran;2. Department of Anatomical Sciences, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran;3. Department of Anatomical Sciences, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran;1. Department of Food and Nutrition Science, College of Agricultural and Food Sciences, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia;2. Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine and Animal Resources, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia |
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| Abstract: | PurposeThe aim of present study was to review and categorize the clinical trials investigating the clinical effects of different botanical parts of dates compared with any controls.MethodsAll clinical trials (randomized, pilot, quasi-experimental, cross-over. and non-randomized clinical trials) evaluating the clinical effects of date palm from 2000 until August 2019 in English and Persian languages were included in this systematic review. The methodological quality of the included studies was evaluated according to the risk of bias assessment of Cochrane handbook of systematic reviews, and then reported using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.ResultsTwenty-six studies met the inclusion criteria. Studies were performed in 8 categories based on different botanical parts of date palm. These categories were obstetrics, gynecology, oncology, dermatology, hematology, gastroenterology, endocrinology, metabolism, and infertility. A total of 38 % of included studies were randomized controlled trials. Further, 80 % of the included studies had performance and detection bias. Finally, about 50 % of them had selection bias and about 20 % had attrition and reporting bias.ConclusionThe widespread consumption of date palm as medicinal and botanical plant suggests the importance of this plant in human healthcare. The clinical trials conducted so far have explained a number of clinical effects of date palm. However, there is not enough clinical evidence to support the clinical effects in other review articles and traditional medical systems, and further randomized controlled trials with robust designs and methods are required. |
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| Keywords: | Date Palm Clinical effects Clinical trials Systematic review |
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