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Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis |
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| Affiliation: | 1. Department of Radiation Oncology, Sheba Medical Center, Ramat-Gan, Israel;2. Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel;3. Shaare Zedek Medical Center, Jerusalem, Israel;4. Hadassah Medical School, The Hebrew University, Jerusalem, Israel;5. Oncology, Kaplan Medical Institute, Rehovot, Israel;6. Oncology Institute, Galilee Medical Center, Naharia, Israel;7. Assuta Medical Center, Tel Aviv, Israel;8. Oncology Division, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel;9. Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel |
| Abstract: | PurposeWe recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer.MethodsFor participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density.ResultsSignificant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group.ConclusionReduction of BPE by PBI may contribute to its prophylactic effect. |
| Keywords: | Breast cancer BRCA Prophylactic breast irradiation BPE |
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