Effect of coenzyme Q10 on endotoxin shock in dogs

We studied the effects of coenzyme Q10 pretreatment on both pulmonary function and chemical mediators during endotoxin shock in dogs. Coenzyme Q10 pretreatment inhibited disturbances in peak airway pressure, total compliance of lung plus chest wall, lung clearance index, plasma histamine, base excess, and lactate; however, it had little effect on the circulation. The mechanism of coenzyme Q10's significant effects on pulmonary function during endotoxin shock is presently unknown.