Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma |
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Authors: | Masato Narita Etsuro Hatano Shigeki Arizono Aya Miyagawa-Hayashino Hiroyoshi Isoda Koji Kitamura Kojiro Taura Kentaro Yasuchika Takashi Nitta Iwao Ikai Shinji Uemoto |
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Institution: | (1) Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;(2) Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;(3) Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan |
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Abstract: | Background Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective
properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma
(HCC).
Methods A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement
ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined.
Results Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately
differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive
HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs
without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r = 0.91, P < 0.0001).
Conclusions Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production. |
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Keywords: | Green hepatoma Gd-EOB-DTPA MRI OATP1B3 HCC |
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