Lactic Dehydrogenase of Human Chronic Lymphocytic Leukemic Leukocytes |
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| Authors: | BOTTOMLEY, RICHARD H. LOCKE, S. J. INGRAM, H. C. |
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| Affiliation: | 1 Cancer Section, Oklahoma Medical Research Institute and the Department of Medicine, University of Oklahoma School of Medicine.
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| Abstract: | Lactic dehydrogenase was quantitated and its isozyme pattern studied inthe leukocytes of 10 patients with chronic lymphocytic leukemia. There wasa wide range of LDH activity, although all isozyme patterns by starch-gelelectrophoresis showed greatest activity in the No. III isozyme band. Comparison of the rate of migration of the leukemic leukocyte LDH with LDHfrom normal leukocytes and erythrocytes showed no difference in migrationrate, suggesting that the LDH of chronic lymphocytic leukemic leukocytesdoes not differ in electrical charge from LDH of normal leukocytes. Submitted on March 4, 1965 Accepted on May 19, 1965 |
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