Early immunoscintigraphic localisation of a mediastinal tumour with indium 111-DTPA CEA-specific F(ab')2 monoclonal antibody fragments (BW 431/31) using second tracer isocontour technique |
| |
Authors: | Jürgen Frohn Richard P. Baum Joachim Happ Stephan Falk Helmut E. Riemann Gustav Hör |
| |
Affiliation: | (1) Department of Radiology, Division of Nuclear Medicine, Frankfurt University Medical Center, Theodor-Stern-Kai 7, D-6000 Frankfurt, Germany;(2) Senckenberg Center of Pathology III, Frankfurt University Medical Center, Theodor-Stern-Kai 7, D-6000 Frankfurt, Germany;(3) Department of Radiology, Division of Diagnostic Radiology III, Frankfurt University Medical Center, Theodor-Stern-Kai 7, D-6000 Frankfurt, Germany |
| |
Abstract: | A female patient with steadily increasing carcinoembryonic antigen (CEA) serum levels of unknown origin was referred for immunoscintigraphy with indium 111-labelled CEA-specific monoclonal antibody. The procedure revealed a tumour, undetectable by conventional diagnostic methods. Anatomical landmarking using the second tracer isocontour technique allowed the distinction between an intra- or extrapulmonary lesion. Two months later, tumour infiltration along the aortic arch was confirmed by a targeted angio-CT scan. Upon surgery, the diagnosis was definitely established histologically (undifferentiated, solid large cell carcinoma, most probably arising from the bronchus), and staining by CEA-specific immunohistochemistry confirmed the presence of the CEA antigen. |
| |
Keywords: | Immunoscintigraphy Monoclonal antibody Carcinoembryonic antigen (CEA) Single photon emission computed tomography (SPET) Indium 111 Anatomical landmarking Second tracer isocontour technique Immunohistochemistry |
本文献已被 SpringerLink 等数据库收录! |
|