| miRNAs 在不同级别宫颈癌中的差异性表达分析及其临床意义 |
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| 引用本文： | 罗燕鸿,林娟娟,叶蕾,孔丹莉,何玉清. miRNAs 在不同级别宫颈癌中的差异性表达分析及其临床意义[J]. 国际遗传学杂志, 2016, 0(3): 162-168. DOI: 10.3760/cma.j.issn.1673-4386.2016.03.008 |
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| 作者姓名： | 罗燕鸿 林娟娟 叶蕾 孔丹莉 何玉清 |
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| 作者单位： | 1. 523808 东莞，广东医科大学公共卫生学院流行病与卫生统计学教研室; 523808，东莞市环境医学重点实验室;2. 广东医科大学公共卫生学院流行病与卫生统计学教研室, 东莞,523808;3. 523808 东莞，广东医科大学医学系统生物学研究所; 523808 东莞，广东省医学分子诊断重点实验室 |
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| 基金项目： | 国家自然科学基金(81201223)；广东省扬帆计划引进紧缺拔尖人才项目(201433005)；广东省科技计划国际合作项目(2013B051000080)；广东省教育厅创新平台特色创新项目(CX14106G)；东莞市科技计划国际合作重点项目(2013508152005)；东莞市社会科技发展重点项目(2014108101055)；广东医学院产学研特色项目( CXY201304)F und program National Science Foundation of China (81201223)； Talents Recruitment Grant of“Yangfan Plan” of Guangdong Province (201433005)； International Science ＆ Technology Cooperation Program of Guangdong (2013 B 051000080)； Innovation Project from the Education Department of Guangdong Province ( CX 14106 G )； International Science ＆ Technology Cooperation Key Project of Dong-guan (2013 5 0 8 1 5 2 0 0 5)； Science ＆ Technology Key Project of Dongguan (2014108101055)；Guangdong Medical University Integration of Industry ， Education and Research (CXY 2013 0 4) |
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| 摘 要： | 宫颈癌是女性常见的恶性肿瘤之一，虽然高危型人乳头瘤病毒持续性感染是导致宫颈癌发生的最主要因素，但是表观遗传学调控在其发展过程中也具有重要作用。研究发现，微小核糖核酸（ microRNAs ， miRNAs ）在不同级别宫颈癌中有明显差异性表达，并广泛参与了宫颈癌发生的各个生物学过程。本文系统分析了85篇实验性文章中报道的不同阶段宫颈癌组织的 miRNAs 差异性表达谱，并将其分别归类到宫颈上皮内瘤样病变1-3级（ cervical intraepithelial neoplasia ， CIN 1-3）和宫颈癌4个病理分级中，为评价 miRNAs 在宫颈癌早期诊断和预后监测中的临床应用价值提供了科学的理论依据。
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| 关 键 词： | 宫颈癌 微小核糖核酸 差异性表达 |
Analysis of the differentially expressed microRNAs at different stages of cervical cancer and its clini-cal significance |
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| Abstract: | Cervical cancer is a kind of common gynecological malignancies . Although human papillomaviruse ( HR-HPV ) persistent infection is considered as the main cause of cervical cancer , the epigenetic regulation also plays an important role in the cancer development .Studies indicate that microR-NAs ( miRNAs ) are differentially expressed at different levels of the cervical cancer , and are involved in various biological processes of the cervical cancer .In this study we analyzed the miRNAs expression pro-files at different stages of the cervical cancer from 8 5 original experimental articles by systematic analysis method , and classified them into four different pathological grades including the cervical intraepithelial neo -plasia ( CIN 1-3 ) and the cervical cancer .The results will provide a theoretical basis for evaluating the clinical application value of the differentially expressed miRNAs in the early diagnosis and the prognosis of cervical cancer . |
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| Keywords: | Cervical cancer MicroRNAs (miRNAs ) Differential expression |
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