生物标志物在阻断PD-1/PD-L1通路治疗肿瘤中的预测性作用 |
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引用本文: | 崔金元,陶凯雄. 生物标志物在阻断PD-1/PD-L1通路治疗肿瘤中的预测性作用[J]. 国际肿瘤学杂志, 2016, 0(6): 452-454. DOI: 10.3760/cma.j.issn.1673-422X.2016.06.014 |
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作者姓名: | 崔金元 陶凯雄 |
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作者单位: | 华中科技大学同济医学院附属协和医院胃肠外科,武汉,430022 |
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基金项目: | 国家自然科学基金(81572413) National Natural Science Foundation of China (81572413) |
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摘 要: | 确定预测PD-1/PD-L1通路阻断治疗临床反应的生物标志物有助于患者筛查和个体化治疗.研究证明治疗前肿瘤组织中肿瘤细胞和肿瘤浸润淋巴细胞PD-L1的高表达,肿瘤间CD8+T细胞的大量浸润以及肿瘤细胞基因高突变负荷的患者阻断PD-1/PD-L1通路治疗的临床疗效更明显,这些生物标志物有望成为筛查肿瘤患者的指标.
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关 键 词: | 肿瘤 治疗 生物学标记 PD-1/PD-L1通路 |
Predictive biomarkers in tumor treatment by blocking PD-1/PD-L1 pathway |
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Abstract: | Identifying biomarkers predicting clinical response to treatment of PD-1/PD-L1 pathway blockade can guide patient selection and therapeutic individualization.Some researches have shown that patients with cancer will acquire better clinical effects by blocking PD-1/PD-L1 pathway whose characteristics include higher pretreatment expression of PD-L1 by tumor cells or tumor infiltrating immune cells,the massive infiltration of intratumoral CD8 + T cells,the high mutation frequency of tumor cell gene.These biomarkers are expected to become indicators which can select patients. |
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Keywords: | Neoplasms Therapy Biological markers PD-1/PD-L1 pathway |
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