TURP术对改善伴有LUTS症状的高龄前列腺癌患者生活质量的研究

目的 探讨经尿道前列腺电切术对伴有下泌尿道症状的高龄前列腺癌患者生活质量的影响.方法 回顾性分析2012年1月-2014年1月徐州医学院附属医院泌尿外科收治的75例经前列腺穿刺取活检病理确诊的高龄前列腺癌患者的临床资料,平均年龄(79±7)岁,其中55例伴有不同程度的下泌尿道症状,26例行经尿道前列腺电切术治疗.后均行规律内分泌治疗,观察记录患者诊治前及诊治后3、6、12个月时IPSS及QOL评分,比较患者生活质量的改变.结果 纳入治疗组的44例患者术后3、6、12个月IPSS评分分别为(6.25±2.53)分、(5.15 ±2.25)分、(5.00±2.36)分,与术前IPSS基础值(30.55±3.62)分比较,差异有统计学意义(P＜0.01),而术后3、6、12个月IPSS评分差异无统计学意义(P =0.209,0.863,0.154).治疗组术后3、6、12个月QOL评分分别为(1.35±1.14)分、(0.85±0.75)分、(0.70±0.87)分,与术前QOL基础值(4.70±0.73)分比较,差异有统计学意义(P＜0.01),而术后3、6、12个月QOL评分差异无统计学意义(P=0.078,0.023,0.593).治疗组及对照组的IPSS及QRI评分比较,治疗前无差异(F=0.105,P=0.747);治疗后差异显著,有统计学意义(P＜0.01).结论 经尿道前列腺电切是一种可以改善排尿困难,改善患者的生活质量,对于失去根治机会的前列腺癌患者不失为一种安全有效的方法.

Research on TURP technique to improve the symptoms of LUTS with elderly PCa patients quality of life

Objeetive To investigate the effect of TURP on the quality of life of elderly PCa patients with LUTS symptoms.Methods A retrospective analysis of the clinical data from January 2012 to January 2014 of 75 patients admitted to our hospital after prostate puncture biopsy and pathological diagnosis of PCa in elderly patients,mean age (79 ± 7) years old,which 44 cases were associated with different degrees of LUTS symptoms,of which,20 underwent TURP.After the rule of endocrine therapy,we observe and record of patients before and after treatment and 3,12,6 months after the IPSS and QOL score,compared with the changes in the quality of life of patients.Results Forty-four cases of patients with IPSS score in treatment group after 3,6 and December were (6.25 ± 2.53),(5.15 ± 2.25),(5.00 ± 2.36).Compared with the preoperative IPSS basal value (30.55 ± 3.62),the difference was statistically significant (P ＜0.01).However,there was no significant difference in the postoperative patients (P =0.209,0.863,0.154).The QOL score of treatment group after 3,6 and 12 months were (1.35 ± 1.14),(0.85 ± 0.75) and (0.70 ± 0.87).Compared with the preoperative QOL basal value (4.70 ± 0.73),the difference was statistically significant (P ＜ 0.01).However,there was also no significant difference in the postoperative patients (P =0.078,0.023,0.593).Compared with the control group of IPSS and QOL score,there was no significant difference before treatment in the treatment group (F =0.105,P =0.747),however,there was significant difference after treatment(P ＜ 0.01).Conclusions TURP is a safe and effective method to improve the quality of life and improve the quality of life of patients with prostate cancer.