尿毒症血液透析患者乳酸脱氢酶水平变化

目的 探讨尿毒症血液透析患者乳酸脱氢酶变化及其临床意义.方法 纳入尿毒症未透析者、尿毒症透析者及正常健康人各15例,采用全自动生化分析仪分别检测血清血红蛋白、肌酐、尿素氮及乳酸脱氢酶水平.结果 尿毒症未透析患者血清乳酸脱氢酶水平较正常健康人明显升高(P＜0.05);尿毒症血液透析组患者透析后乳酸脱氢酶水平与透析前相比有升高,但差异无统计学意义(P＞0.05).结论 尿毒症未透析患者体内乳酸脱氢酶水平的升高无器官特异性,血液透析改变了尿毒症患者体内乳酸脱氢酶环境,乳酸脱氢酶有可能作为评价血液透析充分性的观察指标.

Lactic dehydrogenase changes in uremic hemodialysis patients

Objective To investigate lactic dehydrogenase changes and clinical significance in uremic hemodialysis patients.Methods The serum lactic dehydrogenase levels of 15 normal people,15 uremia non-dialysis patients (non-HD) and 15 hemodialysis patients pre and post HD process were determined by automatic biochemistry analyzer.Results The lactic dehydrogenase level in uremia non-dialysis patients compared with normal control group,there was significant difference (P ＜ 0.05),The serum lactic dehydrogenase levels in the post hemodialysis people were higher than in the groups of the before hemodialysis people(P ＞ 0.05).Conclusion The heighten of lactic dehydrogenase level in uremia non-dialysis patients was no organ specificity,hemodialysis changes lactic dehydrogenase unfit circumstance,lactic dehydrogenase may be as a dialysis effect observation index.