| 子宫内膜异位症相关卵巢癌的发病机制研究 |
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| 引用本文： | 吴海双,刘巍,谭文华. 子宫内膜异位症相关卵巢癌的发病机制研究[J]. 国际遗传学杂志, 2016, 0(4): 218-222. DOI: 10.3760/cma.j.issn.1673-4386.2016.04.009 |
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| 作者姓名： | 吴海双 刘巍 谭文华 |
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| 作者单位： | 哈尔滨医科大学附属第二医院妇产科,150081 |
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| 摘 要： | 子宫内膜异位症相关卵巢癌(EAOC)与其他类型卵巢癌相比,有发病年龄早,一般50岁左右,病变期别较早,且预后很好等特点,目前关于EAOC发病机制的研究尚未定论.但有专家提出,子宫内膜异位症(EMs)增加了卵巢子宫内膜样癌和透明细胞癌的发生风险.EAOC的发生可能与ARID1A、HNF、miRNAs等基因突变,雌激素和氧化应激等因素密切相关.
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| 关 键 词： | 子宫内膜异位症 子宫内膜异位症相关卵巢癌 恶变 |
Research on the pathogenesis of endometriosis-associated ovarian cancer |
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| Abstract: | Endometriosis-associated ovarian cancer (EAOC) characterized by early diagnosis and early onset around 50 years is typically associated with a better prognosis compared to other ovarian cancer subtypes.The pathogenesis of EAOC is still unclear,however investigators have suggested that endometriosis (EMs) is associated with a higher risk of ovarian endometrial cancer and clear cell carcinoma.The EAOC can be caused by mutations in the ARIDIA,the HNF and miRNAs.In addition,EAOC is likely associated with the statue of estrogen and oxidative stress,etc. |
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| Keywords: | Endometriosis Endometriosis-associated ovarian cancer Malignant transformation |
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