| 结肠癌上皮间质转化信号通路机制研究 |
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| 引用本文： | 李晓晴,李袁飞.结肠癌上皮间质转化信号通路机制研究[J].国际肿瘤学杂志,2016(5):385-386. |
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| 作者姓名： | 李晓晴 李袁飞 |
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| 作者单位： | 山西医科大学第一临床医学院肿瘤科,太原,030001 |
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| 基金项目： | 山西省科技攻关项目(201301062)Science and Technology Development of Shanxi Province of China (201301062) |
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| 摘 要： | 上皮间质转化(EMT)在结肠癌发生发展、侵袭转移中发挥重要作用.转化生长因子-β、Wnt/β-catein、Notch、核转录因子-κB、磷脂酰肌醇-3激酶/蛋白激酶B信号通路对结肠癌EMT过程起重要的诱导调控作用.进一步阐明EMT信号通路,可为结肠癌靶向治疗带来更多的机会.
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| 关 键 词： | 结直肠肿瘤 上皮间质转化 |
Signaling pathways of epithelial-mesenchymal transition in colon cancer |
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| Abstract: | Epithelial-mesenchymal transition (EMT) plays a critical role in the carcinogenesis of colon cancer,and promotes the tumor invasion and metastasis.Studies have shown several signals are involved including transforming growth factor-β (TGF-β),Wnt/β-catein,Notch,nuclear factor-κB (NF-κB) and PI3K/Akt signal pathway.It is important to elucidate EMT-related signal pathway thereby providing new insights into possible therapeutic interventions of colon cancer. |
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| Keywords: | Colorectal neoplasms Epithelial-mesenchymal transition |
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