| 肠道病毒71型与宿主相互作用 |
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| 引用本文： | 张小龙. 肠道病毒71型与宿主相互作用[J]. 国际生物制品学杂志, 2016, 0(4): 176-181. DOI: 10.3760/cma.j.issn.1673-4211.2016.04.005 |
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| 作者姓名： | 张小龙 |
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| 作者单位： | 中国医学科学院北京协和医学院医学生物学研究所、云南省重大传染病疫苗研发重点实验室, 昆明,650118 |
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| 基金项目： | 北京协和医学院“协和青年基金”(3332015051),Peking Union Medical College "Xie He Youth Foundation"(3332015051) |
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| 摘 要： | 肠道病毒71型(enterovirus 71,EV71)是引起手足口病的主要病原体之一.EV71传播广泛,感染后可引发中枢神经系统疾病,并导致重症手足口病,给公共卫生安全带来极大挑战.EV71的致病机制与病毒和宿主间的相互作用关系密切,涉及EV71病毒复制、微RNA等多个环节.此文就近年来这些方面的研究进展做一综述.
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| 关 键 词： | 肠道病毒A型,人 病毒复制 微RNAs |
Virus-host interaction of enterovirus 71 |
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| Abstract: | Enterovirus 71 (EV71) is a major causative agent of hand,foot and mouth disease (HFMD).EV71 infection has caused worldwide epidemics and leads to central nervous system diseases and severe HFMD.Prevalence of EV71 has brought great challenges to public health.Pathogenesis of EV71 is closely related to virus-host interaction,involving multiple factors including EV71 replication and microRNA.This review focuses on new progresses in researching interaction between EV71 and host. |
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| Keywords: | Enterovirus A,human Virus replication MicroRNAs |
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