| 液体活检技术在肿瘤诊断领域的研究进展 |
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| 引用本文： | 孙宇乔,贾学渊,于旸.液体活检技术在肿瘤诊断领域的研究进展[J].国际遗传学杂志,2016(6):327-331. |
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| 作者姓名： | 孙宇乔 贾学渊 于旸 |
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| 作者单位： | 哈尔滨医科大学医学遗传学研究室,150081 |
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| 基金项目： | 国家自然科学基金(81272288)；教育厅科学技术研究项目(12541396)；黑龙江省卫生厅一般项目(2013161)；黑龙江省博士后资助项目( LBH-Z15155)@@@@National Natural Science Foundation of China (81272288)； The Education Agen-cy Project of Heilongjiang Province (12541396)； The Health Agency Project of Heilongjiang Province (2013161)； Heilongjiang Postdoctoral Grant (LBH-Z 15155) |
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| 摘 要： | 近年随着人们对循环肿瘤细胞（ circulating tumor cells ， CTCs ）和循环肿瘤 DNA （ circulating tumor DNA ， ctDNA ）的认识逐渐加深，一种新兴的以血液为基础的肿瘤分子诊断应时而生。液体活检（ Liquid biopsy ）提供了一种无创性获得肿瘤相关信息的方式，具有安全，高效，实时等特点。相对于传统组织活检而言，液体活检的出现带来了新的机遇与挑战，其在肿瘤的早期诊断、临床分期、疗效评估和个体化治疗等方面体现出巨大的临床应用前景。虽然液体活检目前尚未在临床上普及，但随着技术的发展，液体活检必将迅速成为精确医学的核心部分。
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| 关 键 词： | 液体活检 肿瘤 循环肿瘤细胞 循环肿瘤DNA |
Research progress of liquid biopsy technology in tumor diagnosis |
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| Abstract: | With increasing understandings of circulating tumor cells ( CTCs ) and circulating tumor DNA , a new molecular diagnosis based on blood analysis emerges .Liquid biopsy is a method to ob-tain information of cancer non-invasively , which has the characteristics of safety , high efficiency and real time .Liquid biopsy provides new opportunities and challenges compared to traditional tissue biopsy .It has demonstrated a remarkably potential of clinical application in early diagnosis , clinical stage , therapeutic e-valuation , and personalized medicine .Liquid biopsy has not been used universally yet ; however , with the development of this technology , it will certainly become one of the central parts of precision medicine in near future . |
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| Keywords: | Liquid biopsy Tumor CTCs ctDNA |
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