High incidence of elevated antibody titers to Epstein-Barr virus in patients with uveitis |
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| Authors: | C Touge H Agawa T Sairenji Y Inoue |
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| Institution: | (1) Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Yonago, Japan;(2) Division of Biosignaling, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan |
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| Abstract: | Summary. We assayed Epstein-Barr virus (EBV) antibody titers in patients’ sera using indirect immunofluorescence and tested for the
presence of antibody to EBV immediate-early BZLF1 protein ZEBRA by Western blotting to explore the association of EBV infection
with uveitis. IgG and IgA antibodies to viral capsid antigen (VCA), IgG antibodies to early antigen (EA), and antibodies to
EBV nuclear antigen were detected at higher titers in sera of patients with uveitis than in the sera of healthy controls.
Neither IgM antibody to VCA nor EA was detected in the patients’ sera. Anti-ZEBRA-IgG antibodies were detected in most patients’
sera, but not in those of healthy controls. These results suggest that uveitis might be a disease accompanied by EBV reactivation. |
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