混合型高脂血症患者血小板活性和纤溶活性的变化

目的 :探讨高脂血症患者血小板活化标志物 GMP- 14 0及纤溶活性的改变。方法 :选择 30例混合型高脂血症患者和 2 0例正常对照组 ,测定血浆α-颗粒膜蛋白 14 0 (GMP- 14 0 )含量及血浆组织型酶原激活物 (t- PA)、t- PA抑制物 (PAI)活性。结果 :高脂血症组较正常对照组血浆 TC、TG、L DL - C明显增高 (P均 <0 .0 1) ,HDL - C下降 (P<0 .0 1)。GMP- 14 0含量、PAI活性明显升高 (P均 <0 .0 1) ,t- PA活性降低 (P<0 .0 1)。PAI- 1活性与 TG呈正相关 (r=0 .4 6 ,P<0 .0 5 )。结论 :高脂血症患者血小板活性明显增加 ,GMP- 14 0水平升高 ;纤溶活性明显降低。

Changes of Platelet Activity and Fibrinolytic Activty in Patients with Combined Hyperlipidemia

Objective To study the changes of platelet activity marker GMP 140 and fibrinolytic activity in hyperlipidemic patients. Methods Thirty combined hyperlipidemic patients and twenty healthy volunteers participated in the study. Serum lipid level, GMP 140, t PA activity and PAI activity were measured in all subjects. Results Compared with normal control group, hyperlipidemic patients showe a significance increase triglyceride and cholesterole concentation in serum, HDL was reduced significantly (P<0.01); the GMP 140 concentation and PAI 1 activity were markedly rose (P<0.01), while t PA activity reduced in hyperlipdemic patients. Conclusion Combinated hyperlipidemic patients showed platelet activity rose (indicated by GMP 140 concntration increased) and hypofibrinolytic activity ascended (indicared by PAI 1 activity elevated and t PA activity reduced)