Proteomics in cancer screening and management in gynecologic cancer |
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Authors: | Wei Hu Weiguo Wu Ryuji Kobayashi John J Kavanagh |
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Institution: | (1) Department of Gynecologic Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 401, 77030 Houston, TX, USA |
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Abstract: | Biomarkers are used routinely for population screening, disease diagnosis and prognosis, monitoring of therapy, and prediction
of therapeutic response. Unfortunately, most biomarkers have low sensitivity and specificity and little predictive value.
Novel techniques for better screening and early diagnosis of ovarian cancer are urgently needed. Proteomics, the study of
the cellular proteins and their activation states, integrates some fundamental techniques, including high-throughput protein
purification and profiling, genomic and proteomic databases, and mass spectrometry. In oncology, proteomics will contribute
greatly to our understanding of gene functions in tumor development and provide information in clinical applications. This
article reviews proteomic techniques and their potential applications in gynecologic cancer screening and management. |
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