| 胍丁胺对吗啡诱导大鼠自身给药行为形成及复吸的影响 |
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| 引用本文： | 苏瑞斌,王卫平,路新强,吴宁,刘志民,李锦.胍丁胺对吗啡诱导大鼠自身给药行为形成及复吸的影响[J].军事医学科学院院刊,2008,32(3). |
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| 作者姓名： | 苏瑞斌 王卫平 路新强 吴宁 刘志民 李锦 |
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| 作者单位： | 1. 军事医学科学院毒物药物研究所,北京,100850
2. 北京大学中国药物依赖性研究所,北京,100083 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 目的:研究胍丁胺的精神依赖潜能及其对吗啡诱导大鼠自身给药模型形成和复吸行为的影响.方法:采用大鼠自身给药模型.结果:胍丁胺(80 mg/kg/INJ)不能替代吗啡(0.5 mg/kg/INJ)诱导的自身给药行为.胍丁胺(40, 80 mg/kg, i.g.)可显著抑制吗啡诱导大鼠自身给药行为的形成,表现为自身给药模型建立潜伏期延长,触鼻次数和每日用药总量明显降低.熄灭期胍丁胺(40, 80 mg/kg, i.g.)治疗能显著抑制吗啡自身给药模型重建,表现为重建潜伏期明显延长,触鼻次数和每日用药总量明显降低.结论:胍丁胺自身无吗啡样致依赖潜能,显著抑制吗啡诱导的奖赏效应,具有抗吗啡精神依赖和防复吸作用.
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| 关 键 词： | 吗啡 胍丁胺 自身给药 复吸 |
Effect of agmatine on morphine-induced intake and re-intake in the rat self-administration model |
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| SU Rui-Bin,WANG Wei-Ping,LU Xin-Qiang,WU Ning,LIU Zhi-min,LI Jin.Effect of agmatine on morphine-induced intake and re-intake in the rat self-administration model[J].Bulletin of the Academy of Military Medical Sciences,2008,32(3). |
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| Authors: | SU Rui-Bin WANG Wei-Ping LU Xin-Qiang WU Ning LIU Zhi-min LI Jin |
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| Institution: | SU Rui-Bin1,WANG Wei-Ping2,LU Xin-Qiang1,WU Ning1,LIU Zhi-min2,LI Jin1(1. Beijing Institute of Pharmacology , Toxicology,Academy of Military Medical Sciences,Beijing 100850,China,2. National Institute of Drug Dependence in China,Beijing 100083,China) |
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| Abstract: | Objective:To investigate the dependent liability of agmatine and the possible effect of agmatine on morphine induced drug self-administration and relapse.Methods:A rat morphine self-administration model was used. Results:Agmatine (80 mg/kg/INJ) did not substitute morphine (0.5 mg/kg/INJ) induced self-administration, which indicated that agmatine itself had no psychological dependent liability. Agmatine (40, 80 mg/kg, i.g.) inhibited rather than completely blocked the acquisition of intravenous morphine self... |
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| Keywords: | morphine agmatine drug self-administration relapse |
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