Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell conditioned medium do not change with age |
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| Authors: | Pfeilschifter J Diel I Klöppinger T Bismar H Schuster E M Balbach S Ziegler R Baylink D Mohan S |
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| Affiliation: | Kliniken Bergmannsheil, Department of Internal Medicine, University of Bochum, Bochum, Germany. johannes.pfeilschifter@ruhr-uni-bochum.de |
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| Abstract: | We examined the effects of age on the secretion of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in long-term bone cell cultures from 71 female donors, aged 28-79 years. Our results suggest that under basal conditions, the intrinsic capacity of human bone cells to produce these IGF components is largely preserved with age. |
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