病理性过期妊娠胎盘功能测定的临床意义

目的：研究胎儿过熟综合征（病理性过期妊娠）时母血、脐血及羊水中 Ｆ Ｅ３ 及 Ｈ Ｐ Ｌ 变化的临床意义。方法：采用放射免疫检测方法对 ４０ 例妊娠 ４０ 周后伴胎儿过熟综合征病例及 ４２ 例生理性过期妊娠肘静脉血、脐静脉血及羊水中 Ｆ Ｅ３ 及 Ｈ Ｐ Ｌ 进行检测，同时与５０ 例足月妊娠进行对照。结果：病理性过期妊娠组母血、脐血及羊水中 Ｆ Ｅ３ 浓度显著低于其它组，各样本 Ｈ Ｐ Ｌ 浓度从足月妊娠至病理性过期妊娠急剧下降，各组间有统计学意义。结论： Ｆ Ｅ３ 和 Ｈ Ｐ Ｌ 能准确反映足月妊娠后胎盘功能下降程度，提示病理性过期妊娠时低体重儿发生率高与胎盘 Ｈ Ｐ Ｌ 合成减少有关。

Clinical value of the test of placental function in the pathological postmature pregnancy

Objective:To study the clinical significance of freeestriol (FE 3) and human placental lactogen (HPL) in the elbow vein blood,umbilical vein blood and amniotic fluid with postmaturity syndrome.Methods:Radiatimmunity test was applied to test 40 cases of pregnancies after 40 weeks with postmaturity syndrome (pathological postmature pregnancy) and 42 cases of physiological posterm pregnancies,50 cases of term pregnancies as control.Results:The results suggested that FE 3 in two blood samples and amniotic fluid of pathological postmature pregnancy group were reduced significantly than those of other groups.HPL level of different samples were reduced significantly from term pregnancy to pathological postmature pregnancy.Conclusion:These results suggested that HPL and FE 3 could exactly and quickly reflect the reduced degree of placental function. The increasing of low birth weight infants in pathological postmature pregnancy was considered as results of HPL level reducing.